Nutrition Evidence Alert – January 2024 – The Microbiome and its Many Associations with Health

From our Experts

Bifidobacterium longum subsp. longum Reduces Perceived Psychological Stress in Healthy Adults: An Exploratory Clinical Trial in Nutrients. 2023. With Expert Review from Ana-Paula Agrela

Early life gut microbiota profiles linked to synbiotic formula effects: a randomized clinical trial in European infants in The American Journal of Clinical Nutrition. 2023. With Expert Review from Wilma Kirsten

Comparative analysis of the efficacies of probiotic supplementation and glucose-lowering drugs for the treatment of type 2 diabetes: A systematic review and meta-analysis in Frontiers in Nutrition. 2022. With Expert Review from Kirsty Baxter

This month, we are kicking off a 3-month focus on the microbiome. This first alert, in what will become a microbiome series, aims to highlight the significant breadth of health implications of the microbiome. From different life stages, bodily systems and disease states, the science on the microbiome is building. Next month, we will focus on the microbiome and IBS and in March on microbiome/IBD associations.

Scroll for more nutrition and lifestyle science


Podcasts Selected for you This Month

Stop Taking Probiotics (Maybe…) – Grace Kingswell in conversation with Alex Manos. State of Mind Podcast

Leveraging your microbiome for better skin, mood, and brain health, plus why most probiotics suck – Max Lugavere in conversation with Kiran Krishnan. The Genius Life Podcast


Your Reference Library

For practitioners, researchers, policy makers and students with particular interest in this area, here’s our long list

Early Life and the Microbiome:

Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial in Nature Communications. 2022

Early life gut microbiota profiles linked to synbiotic formula effects: a randomized clinical trial in European infants in The American Journal of Clinical Nutrition. 2023

Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants in Cell Host & Microbe. 2022

Effect of an Exclusive Human Milk Diet on the Gut Microbiome in Preterm Infants: A Randomized Clinical Trial in JAMA Network Open. 2023

Source of human milk (mother or donor) is more important than fortifier type (human or bovine) in shaping the preterm infant microbiome in Cell Reports. Medicine. 2022

Intestinal Microbial Composition of Children in a Randomized Controlled Trial of Probiotics to Treat Acute Gastroenteritis in Frontiers in Cellular and Infection Microbiology. 2022

Effect of Lacticaseibacillus paracasei N1115 on Immunomodulatory and Gut Microbial Composition in Young Children: A Randomized, Placebo-Controlled Study in Nutrients. 2023

Pre-diabetes/Type 2 Diabetes and the Microbiome:

High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients in Frontiers in Cellular and Infection Microbiology. 2023

White common bean extract remodels the gut microbiota and ameliorates type 2 diabetes and its complications: A randomized double-blinded placebo-controlled trial in Frontiers in Endocrinology. 2022

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study in Gut Microbes. 2022

Randomized controlled trial demonstrates response to a probiotic intervention for metabolic syndrome that may correspond to diet in Gut Microbes. 2023

The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: a GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials in European Journal of Nutrition. 2023

The Effect of Probiotic Supplements on Metabolic Parameters of People with Type 2 Diabetes in Greece-A Randomized, Double-Blind, Placebo-Controlled Study in Nutrients. 2023

The causal relationship between gut microbiota and type 2 diabetes: a two-sample Mendelian randomized study in Frontiers in Public Health. 2023

Impact of dietary interventions on pre-diabetic oral and gut microbiome, metabolites and cytokines in Nature Communications. 2023

Effects of Gut Microbiome Modulation on Reducing Adverse Health Outcomes among Elderly and Diabetes Patients during the COVID-19 Pandemic: A Randomised, Double-Blind, Placebo-Controlled Trial (IMPACT Study) in Nutrients. 2023

Non-alcoholic Fatty Liver Disease and the Microbiome:

Gut microbiota in nonalcoholic fatty liver disease: a PREDIMED-Plus trial sub analysis in Gut Microbes. 2023

A Low Glycemic Index Mediterranean Diet Combined with Aerobic Physical Activity Rearranges the Gut Microbiota Signature in NAFLD Patients in Nutrients. 2022

Overweight/Obesity and the Microbiome:

Consumption of Extruded Sorghum SC319 Improved Gut Microbiota at Genus Level and Reduced Anthropometric Markers in Men with Overweight: A Randomized Controlled Clinical Trial in Nutrients. 2023

Effects of Synbiotic Supplementation on Metabolic Syndrome Traits and Gut Microbial Profile among Overweight and Obese Hong Kong Chinese Individuals: A Randomized Trial in Nutrients. 2023

Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on Overweight and the Gut Microbiota in Humans: Randomized, Double-Blinded, Placebo-Controlled Clinical Trial in Nutrients. 2022

The Effects of High Fiber Rye, Compared to Refined Wheat, on Gut Microbiota Composition, Plasma Short Chain Fatty Acids, and Implications for Weight Loss and Metabolic Risk Factors (the RyeWeight Study) in Nutrients. 2022

Aspects of Aging and the Microbiome:

One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density in NPJ Biofilms and Microbiomes. 2022

Effects of Lactiplantibacillus plantarum OLL2712 on Memory Function in Older Adults with Declining Memory: A Randomized Placebo-Controlled Trial in Nutrients. 2022

The effect of vitamin D supplementation on the gut microbiome in older Australians – Results from analyses of the D-Health Trial in Gut Microbes. 2023

Stress, Mood and the Microbiome:

Effects of Lactococcus lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute psychological stress in healthy Japanese men in European Journal of Clinical Nutrition. 2022

Multispecies probiotic administration reduces emotional salience and improves mood in subjects with moderate depression: a randomised, double-blind, placebo-controlled study in Psychological Medicine. 2023

Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study in Nutrients. 2023

Food, Fibre, Pre- and Pro-biotics and the Microbiome:

Effect of ancient Khorasan wheat on gut microbiota, inflammation, and short-chain fatty acid production in patients with fibromyalgia in World Journal of Gastroenterology. 2022

Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial in Gut Microbes. 2023

Walnut consumption and gut microbial metabolism: Results of an exploratory analysis from a randomized, crossover, controlled-feeding study in Clinical Nutrition (Edinburgh, Scotland). 2023

Interactions between Mediterranean Diet Supplemented with Dairy Foods and the Gut Microbiota Influence Cardiovascular Health in an Australian Population in Nutrients. 2023

Oral intake of Lactiplantibacillus pentosus LPG1 Produces a Beneficial Regulation of Gut Microbiota in Healthy Persons: A Randomised, Placebo-Controlled, Single-Blind Trial in Nutrients. 2023

Menopause and the Microbiome:

Effects of Lactobacillus gasseri CP2305 on Mild Menopausal Symptoms in Middle-Aged Women in Nutrients. 2022



Download our NED InfoBites for a snapshot of the latest science

Our scientific NED InfoBites are especially designed to provide you with our pick of the latest research in a handy one-page pdf, ideal for sharing with colleagues and clients.

Many of the studies have been reviewed by our dedicated Expert Review Panel to evaluate the clinical applications of recent research in a clinical setting.

Head over to our Youtube channel to listen to our Expert Reviewers discussing the science in NED Talks and browse our digital NED Journal.

Discover all available NED InfoBites here 

Download our Fact Sheets, designed to provide a simple overview of many common diseases and symptoms.

Our Fact Sheets provide an overview of many common health conditions and symptoms that can be supported with personalised nutrition and lifestyle interventions.

Discover all available Fact Sheets here


Discover the BANT Food for your Health Toolbox

The BANT ‘Food for your Health’ toolbox of resources highlights the role of nutrition as prevention for poor health and diet-induced illness.

The toolbox is designed to encourage people to look at their diet with new eyes and to adopt a food-first approach as prevention for chronic disease.

Our free resources are designed to help distill nutritional science into practical client-friendly resources which educate on the importance of good nutrition, healthy food choices, and supportive lifestyle habits. More importantly, they help empower individuals to have greater autonomy over their health and wellbeing outcomes.

Discover a range of food & lifestyle guides, informative infographics, fact sheets and recipes here.

These resources provide a great introduction to nutrition and lifestyle considerations however, for more personalised recommendations, find a Registered Nutritional Therapy Practitioner here.



Print Friendly, PDF & Email

Print Friendly, PDF & Email